Interestingly, NOS2 gene involved in controlling infection of a closely related mycobacteria, M. tuberculosis (Kutsch et al., 1999; Velez et al., 2009), was significantly induced (>100 fold) in both vaccine groups, suggesting an important role of this gene in adaptive immune responses following immunization with LAV (Table 5) or inactivated (Table 6) vaccine. This evidence concerns the gene NOS2 and infection.