WEE1 and cancer: Prior work has demonstrated that ectopic high-expression of WEE1 has been identified in several malignant tumors and associated with poor outcome, such as glioblastoma (Music et al., 2016), vulvar squamous cell carcinoma (Magnussen et al., 2013), ovarian carcinoma (Slipicevic et al., 2014), melanoma (Magnussen et al., 2012), and colorectal carcinoma (Egeland et al., 2016; Ge et al., 2017).