This study demonstrated the correlation among cytokines IL-1β, NLRP3 blood concentration and Escherichia/Shigella in the Amy+ and Amy- group, and the absence of correlation between IL-1β and CXCL2 with E. rectale in the Amy+ and Amy- groups; thus, the study concluded that the increase in pro-inflammatory gut bacteria, e.g., Escherichia/Shigella, and the decrease in anti-inflammatory gastrointestinal bacteria, e.g., E. rectale, might be one part of Alzheimer’s disease pathology (Cattaneo et al., 2017). The gene discussed is IL1B; the disease is early-onset autosomal dominant Alzheimer disease.