Interestingly, the mTOR inhibitor-Rapamycin treatment resulted in the induction of Uchl1 protein by association of shuttling Uchl1-AS from the nucleus to the cytoplasm, suggesting that the interaction between Uchl1–ncRNA–mTOR may be critical for PD development (Carrieri et al., 2012; Vucićević et al., 2014). Here, UBE3A is linked to Parkinson disease.