SRC and central nervous system cancer: In reverse, as a substrate of c-Src, the upregulation of Cx43 in glioma cells reduced the c-Src activity by decreasing phosphorylated c-Src at tyrosine 416 and by increasing the inactive form of Src (phosphor-Src Tyr527; Herrero-González et al., 2010; Gangoso et al., 2014), while downregulation or silencing of Cx43 activated c-Src promoted proliferation and increased the rate of glucose uptake (Gangoso et al., 2012; Valle-Casuso et al., 2012).