KCNN4 and Alzheimer disease: In this review we have highlighted the similarities between rodent and human microglia transcriptomics and have identified key ion channels prominent in human iPSC-derived microglia, some of which we have already been highlighted earlier in this review as prominent targets associated with AD (Table 2) including KCNK13, KCNN4, TRPV2, HVCN1, and CLIC1.