We suspect that these changes in K+ channel expression form part of the age-related changes in microglial function, documented by several lines of investigation, such as altered responses to Aβ aggregates or downregulation of “sensome” genes (Hickman et al., 2008; Cameron et al., 2012; Heneka et al., 2013; Hickman and El Khoury, 2013; Johansson et al., 2015) ever, this downregulation is not reflected in a human study in which Kv1.3 expression remains robust in microglia, particularly in the later stages of AD (Rangaraju et al., 2015). The gene discussed is KCNA3; the disease is Alzheimer disease.