It appears from the literature that Kv1.3, KCa3.1, and Kir 2.1 inhibitors seem to constitute relatively general anti-inflammatory effects and it could therefore be useful to preferentially target detrimental pro-inflammatory microglia functions associated with neuro-inflammation, such as AD (Nguyen et al., 2017b). This evidence concerns the gene KCNA3 and Alzheimer disease.