In another report, BORIS expression was significantly associated with lymph node metastasis in esophageal squamous cell cancer (ESCC), and patients with BORIS-positive tumors had a poor overall survival in this cancer, suggesting that BORIS is associated with metastatic activity of ESCC cells in the early stage and BORIS can be considered as a potential biomarker for esophageal cancer patients with a poor prognosis [49]. The gene discussed is CTCFL; the disease is metastatic malignant neoplasm in the lymph nodes.