In addition to CT genes, BORIS participates in regulation of some non-CT genes such as BRCA1, Oct-3/4 (POU5F1), MYC, Rb2/p130, SBSN and hTERT (human telomerase reverse transcriptase) which are known to be involved in cancer progression [30, 34, 68, 69] (Figs. 1, 2). The gene discussed is CTCFL; the disease is cancer.