Finally, among the breast cancer predisposition genes with moderate/high-penetrance16,26, seven genes (BMPR1A, PTEN, CDH1, NF1, RAD51C, BRIP1, and CHEK2) were replicated for Korean BRCAX (eight for Asian and 15 genes for European high-risk breast cancers, Supplementary Table S8). This evidence concerns the gene CHEK2 and breast cancer.