However, activation of Rac or AKT may also stimulate NOX2-derived superoxide production [38, 39] and in the myeloid leukemia model employed in the present study the ROS levels were reduced by > 50% in Nox2−/− vs. Nox2+/+KrasG12D myeloid cells. The gene discussed is AKT1; the disease is myeloid leukemia.