Based on our phenotypic results and key genes significantly altered (FDR < 0.1) in the regressing tumors we have developed a working model (Fig. 8), whereby we link oncogenic Ras, DNA damage, type I IFN response, TNF, TRAIL, death receptors, and p53 pathway to the apoptotic response and tumor regression observed in C/EBPβ-depleted tumors. Here, TNF is linked to neoplasm.