Irradiated tPA−/−;uPA−/− mice did not develop any form of radiodermatitis at any time point after irradiation (Fig. 5a), and plasminogen levels in the irradiated skin of these mice were significantly lower than in irradiated tPA+/+;uPA+/+ mice (Fig. 5b), indicating that the total plasminogen accumulation partially depends on the activation of plasminogen into plasmin. The gene discussed is PLAT; the disease is radiodermatitis.