The plg+/− mice, which have half the plasminogen level as that of plg+/+ mice, developed erythema and mild desquamation around days 9 to 10, which healed before day 20 and never progressed to a severe form of radiodermatitis (Fig. 1b, d, and Supplementary Fig. 1). The gene discussed is PLG; the disease is radiodermatitis.