A number of the selected genes have been shown to be related to disease states (using diseases tool—diseases.jensenlab.org) such as lysosomal storage diseases, including Niemann-Pick (Glb1 and Gal3st), Fabry (Psap), Krabbe disease (Glb1 and Psap), Hermansky-Pudlak syndrome (Tsg101 and Vps16), some of which have been associated with deficient iNKT cell differentiation as well as defective antigen presentation27. This evidence concerns the gene PSAP and lysosomal storage disease.