A number of the selected genes have been shown to be related to disease states (using diseases tool—diseases.jensenlab.org) such as lysosomal storage diseases, including Niemann-Pick (Glb1 and Gal3st), Fabry (Psap), Krabbe disease (Glb1 and Psap), Hermansky-Pudlak syndrome (Tsg101 and Vps16), some of which have been associated with deficient iNKT cell differentiation as well as defective antigen presentation27. Here, VPS16 is linked to lysosomal storage disease.