SHQ1 and acute lymphoblastic leukemia: We next analyzed MYC-regulated aerobic glycolysis upon SHQ1 deficiency and found significantly impaired glucose uptake and lactate secretion in SHQ1-depleted HPB-ALL and KOPTK1 cells (Fig. 7e and Supplementary Fig. 13a), associated with downregulation of MYC target genes implicated in glycolysis (Fig. 7f and Supplementary Fig. 13b).