We next analyzed MYC-regulated aerobic glycolysis upon SHQ1 deficiency and found significantly impaired glucose uptake and lactate secretion in SHQ1-depleted HPB-ALL and KOPTK1 cells (Fig. 7e and Supplementary Fig. 13a), associated with downregulation of MYC target genes implicated in glycolysis (Fig. 7f and Supplementary Fig. 13b). Here, MYC is linked to acute lymphoblastic leukemia.