Four case-specific and one control-specific non-synonymous heterozygous mutations (p.Q237H, p.W271G, p.T312K fs*55 and p.S520R in 417 CHD patients, p.A729V in 213 healthy controls) were identified within MIB1 gene coding region (Figure 1 and Supplementary Table S2), which are absent in dbSNP, the 1000 genomes project, the Exome Aggregation Consortium (ExAC) and the Genome Aggregation Database (gnomAD). This evidence concerns the gene MIB1 and coronary artery disorder.