Activation of the Nuclear Factor of κ light polypeptide gene enhancer in B-cells (NF-κB) pathway in astrocytes, through a conditional knock-out of the IκBα inhibitor or by expression of a constitutively active IKK, increases glial reactivity in the cortex and hippocampus of WT and AD mice [44, 60]. The gene discussed is NFKB1; the disease is Alzheimer disease.