Typically in quiescent cells, Yap1 is phosphorylated downstream of the tumor suppressive Hippo pathway, by Lats1 and Lats2 kinases; phosphorylation leads to its sequestration in the cytoplasm by 14–3-3 proteins resulting in proteasomal degradation, thereby preventing its nuclear import [52]. The gene discussed is LATS1; the disease is neoplasm.