Multiple associations between signaling pathways or networks might have orchestrated NF-κB activation [32]; a previous study showed that TGEV induced NF-κB activation through RLR-mediated signaling in PK-15 cells [29] and Yang’s results also indicate that there are at least two convergent pathways associated with NF-κB activation that are induced by TGEV infections in ST cells, IKK-2_IκBα/P65 and JAK2 [7]. Here, RELA is linked to infection.