TRPC6 and idiopathic pulmonary arterial hypertension: Moreover, single-nucleotide polymorphisms (SNPs) are found in the KCNA5 gene (Kv1.5, Potassium Voltage-Gated Channel Subfamily A Member 5) [16,17] and the TRPC6 (for Transient Receptor Potential Canonical 6) gene promoter may predispose individuals to an increased risk of IPAH [18] but, to date, KCNK3 mutations are the first channelopathies known to cause PAH [11].