ANO1 and cyclic hematopoiesis: In endothelium-denuded pulmonary arteries of CH rats, the enhanced contractile response is prevented by T16A(inh)-A0a (a TMEM16A inhibibitor) and by the Ca2+-activated Cl− channels niflumic acid but also by the L-type Ca2+ channel antagonist nifedipine, supporting the relevance of the Ca2+-activated Cl− channels in vasomotor tone in the pulmonary circulation under disease conditions.