Besides, genes related to mitochondrial biogenesis and dynamics (PPARα, PGC1α, Mfn2, Tfam, Opa1, Nrf1, Tfb2m) were downregulated in brown adipose tissue of HFG animals when compared to C. This general downregulation is less pronounced in HFF, showing even an upregulation of PGC1β compared to C. Mitochondrial biogenesis and dynamics are very important to keep mitochondrial machinery and genome [4], being the downregulation of these dynamics in HFG a strong indicator of mitochondrial damage and dysfunction. Here, NRF1 is linked to hand-foot-genital syndrome.