CASP3 and brain injury: Additional studies are warranted to determine spatiotemporal profiles of some important caspase-3-mediated protein cleavage products reported in patients with brain injuries such as caspase-3-cleaved cytokeratin-18 (CCCK-18) [90] and 120- and 150-kDa αII spectrin breakdown products (SBDP120 and SBDP150, respectively) [91,92,93] (see also review by Glushakova and colleagues [37]).