Prostate cancer cell-derived EVs contain tumor growth factor (TGFβ) and stimulate the differentiation of bone-marrow mesenchymal stem cells (BM-MSCs) into myofibroblasts, which secrete high levels of VEGF-A, HGF and MMPs such as MMP-1, -3 and -13, have pro-angiogenic functions and enhanced tumor cell proliferation [98]. This evidence concerns the gene TGFB1 and neoplasm.