As for its differential expression pattern on the three glioma subtypes, IGFBP2 has been confirmed to be highly expressed in gliomas with high malignancies, such as glioblastoma and anaplastic astrocytoma, but expressed low in the relatively binary astrocytoma, the diffuse astrocytoma [49,50]. Here, IGFBP2 is linked to astrocytoma (excluding glioblastoma).