Furthermore, miR-155 influences the chromosomal instability by direct down-regulation of centromere protein F (CENPF), zw10 kinetochore protein (ZW10) and BUB1 mitotic checkpoint serine/threonine kinase (BUB1) in CLL cell line [133]. The gene discussed is BUB1; the disease is B-cell chronic lymphocytic leukemia.