MiR-29b-1 interplays with AML1-ETO, the oncogenic fusion protein encoded by the chromosomal translocation t(8;21), which frequently occurs in AML; Zaidi et al. found that runt related transcription factor 1 (RUNX1, also known as AML1) and RUNX1 translocation partner 1 (RUNX1T1, also known as ETO) fusion proteins (AML1-ETO) down-regulates the expression of miR-29b-1, that in turn could down-regulates AML1-ETO expression by direct targeting the ETO 3′UTR. Here, RUNX1T1 is linked to acute myeloid leukemia.