TP53 and myelodysplastic syndrome: MiR-125b-1 is involved in the chromosomal translocation t(2;11)(p21;q23), which leads to myelodysplastic syndromes (MDS) and AML [147]; its over-expression blocks apoptosis through down-regulation of multiple genes implicated in the TP53 pathway, and gives proliferative support to human and mouse myeloid cell lines [148].