APAF1 and rheumatoid arthritis: Moreover, the enhanced expression of miR-155 in RA monocytes reduces both the apoptosis by targeting caspase 10 (CASP10), apoptotic peptidase activating factor 1 (APAF1), and the expression of the chemokine C-C motif chemokine receptor 2 (CCR2), whereas increases the C-C motif chemokine receptor 7 (CCR7) and the secretion of C-C motif chemokine receptor 3/4/5 and 8 (CCL3, CCL4, CCL5, and CCL8).