Mutations in the genes encoding the TAR-DNA binding protein (TDP-43) (TARDBP), fused in sarcoma (FUS) (FUS), TANK-binding kinase-1 (TBK-1), Ubiquilin 2 (UBQLN2), optineurin (OPTN), and Cyclin F (CCNF), are also present in both ALS and FTD patients [16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. Here, OPTN is linked to amyotrophic lateral sclerosis.