IGF1R and lymphopenia: Indeed, serious side effects, such as anemia (9%), hyperglycemia (10%), lymphopenia (14%), oral mucositis (11%), and thrombocytopenia (11%), have been observed in clinical trials with the concurrent therapy of insulin-like growth factor-1 receptor (IGF-1R) inhibitor, cixutumumab, and temsirolimus (a derivative of rapamycin) in patients with bone or soft-tissue sarcoma [40].