Mechanistically, emodin suppresses cell growth and proliferation through the attenuation of oncogenic growth signaling, such as Wnt/β-catenin, HER-2 tyrosine kinase, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (AKT), which leads to apoptosis in several cancer cell types [7,8,9]. This evidence concerns the gene AKT1 and cancer.