In vivo expression analysis of a subset of Tau-interacting genes performed in brain from wild type (WT), Tau-deficient (KOTau) and THY-Tau22, a transgenic model of AD-like tauopathy (28), mice revealed a role for Tau protein in repressing the expression of Tau-interacting genes specially in the context of stress-induced gene-expression. This evidence concerns the gene MAPT and tauopathy.