Among the ten most significant canonical pathways generated by IPA from the list of Tau-interacting genes (Figure 5A), the majority of the pathways were directly related with the biology of neurons and several of them (i.e. CREB signaling in neurons, Synaptic long-term potentiation, Ephrin signaling, c-AMP signaling, ERK/MAPK signaling) have been described as disturbed in AD (40–45) potentially linking Tau-interacting genes with tauopathies. The gene discussed is CREB1; the disease is tauopathy.