Previous research from our group as well as others, working in the field of tauopathies, has shown (i) a nuclear distribution for Tau protein in neuronal and non-neuronal cells (11,17,18), (ii) that Tau protein binds nucleic acids and forms protein-DNA complexes (11,19–21), (iii) that gene expression deregulation accompanies the development of tauopathies (22–26) and (iv) modifications in chromatin architecture and genome organization in the AD brain (27). The gene discussed is MAPT; the disease is tauopathy.