MAPT and Alzheimer disease: A potential role for Tau protein in genome spatial organization would be in line with defects in genome organization that have been observed in the context of Tau deficiency and pathology (14,15,18) and of interest in face of recent studies that point out the contribution of genome organization and 3D structure of chromosomes in neuronal function and plasticity (54), including a role for deregulation of genome organization in relation with aging and AD (27).