We found that induction of Ifnb1, Isg56, Cxcl10 and Il6 genes were significantly inhibited in Snx8-/- bone marrow-derived macrophages (BMDMs) and mouse lung fibroblasts (MLFs) in comparison with their wild type counterparts after infection with three different types of DNA viruses, including HSV-1, vaccinia virus (VV), and ectromelia virus (ECTV) (Fig 2A and S1A Fig). The gene discussed is IFIT1; the disease is infection.