Although studying keratinocyte and explant cultures cannot fully reflect all of the processes ongoing in psoriatic lesions, such cultures are very useful for modelling and testing specific processes and pathways shown to be present in psoriatic disease, and as such these data demonstrate that rhodomyrtone can suppress keratinocyte inflammatory responses to IL-17A and TNF-α, potentially a useful clinical approach for the treatment of inflammation and psoriasis. The gene discussed is TNF; the disease is psoriasis.