RNA-seq data from NHK treated with TNF and rhodomyrtone confirmed the inhibitory effect of rhodomyrtone, particularly on the IL-17A/TNF induction of DEFB4, IL36G, and CXCL1, all known to be highly expressed in psoriasis lesions and investigated as potential biomarkers [33, 34] (Fig 4 and S1 Table). Here, DEFB4B is linked to psoriasis.