IREB2 and nutritional disorder: The distinct distribution of ferritin in renal epithelial cells of iron overloaded mice and of mice suffering from a functional iron deficiency (Irp2-/- mice) suggests that iron status regulates the trafficking of ferritin containing vesicles, which are located near the apical membrane, in iron deficient cells, and are dispersed throughout the cell and near the basolateral membrane in iron overloaded cells.