For example, while many SNPs in SNCA, the gene that encodes alpha-synuclein, have been strongly associated with both familial and sporadic Parkinson's disease (Campêlo and Silva, 2017; Stefanis, 2012), less is known about the mechanism by which non-coding SNPs in SNCA contribute to disease risk. The gene discussed is SNCA; the disease is Parkinson disease.