TOR1A and nervous system disorder: TorsinA, the founding member of the Torsin family, is a constitutively inactive AAA+ protein of medical importance as a three-base pair (ΔGAG) deletion that removes one of a pair of glutamic acid residues (Glu-302/303) in proximity of its C-terminus is linked to DYT1, a neurological disorder that leads to uncontrollable muscular movements (Ozelius et al., 1997).