A prominent example is the c-Jun NH2-terminal kinase (JNK)-interacting protein 1 (JIP1) that is involved in the anterograde transport of the amyloid precursor protein (APP), a key determinant in Alzheimer’s disease (Matsuda et al., 2001; Scheinfeld et al., 2002). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.