IGHE and asthma: In COAST1, LRI and wLRI frequency at age 2 were predictive of asthma diagnosis at age 6 (GLMs with demographic covariates, p=0.02 and 0.02, respectively), while in COAST2, HDM IgE at age 3, and LRI, wLRI and fLRI frequencies at age were all predictive (GLMs, p<0.05 for all) (Figure 5—figure supplement 4).