While Ral proteins have been involved in several cancers frequently carrying Ras mutations, such as pancreas, lung, colon, bladder, melanoma (Yan and Theodorescu, 2018), their roles have not been explored in breast cancers, in which the Ras mutation frequency is rather low (2.3%) (cbioportal) (Gao et al., 2013). The gene discussed is RALA; the disease is melanoma.