In invasive ductal carcinoma, RalB protein expression was slightly higher in luminal A and B than in HER2 +and triple-negative (TN) tumors (Figure 7—figure supplement 1B), while RalA protein expression was slightly lower in TN tumors as compared to the other subtypes (Figure 7—figure supplement 1C). The gene discussed is ERBB2; the disease is invasive ductal breast carcinoma.