Besides the cancer context, we previously found that RalB, but not RalA, controls the mesenchymal migration of normal cells (NRK, HEK-HT, wild-type for Ras) by mobilizing its effector exocyst (Rossé et al., 2006; Parrini et al., 2011; Biondini et al., 2016), which is an octameric protein complex involved in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion (Wu and Guo, 2015). Here, RALB is linked to cancer.