RALB and neoplasm: Moreover, in vivo metastasis assays in mice (tail vein injection) (Ward et al., 2001; Lim et al., 2006) and in hamsters (subcutaneous injection) (Rybko et al., 2011) supported a function of RalB pathway in the formation of tumor metastasis, both in Ras-mutated and Rous sarcoma virus-transformed cells.