TP53 and breast carcinoma: A previous study revealed that the nucleolus senses various stresses and plays a co‐ordinating role in activating p53.31 The mechanisms underlying how RRS1 knockdown inhibits proliferation in breast cancer are currently unknown; however, because RRS1 is one of the rRNA processing factors in ribosome biogenesis, we speculated that it may affect breast cancer proliferation by activating p53.