A previous study revealed that the nucleolus senses various stresses and plays a co‐ordinating role in activating p53.31 The mechanisms underlying how RRS1 knockdown inhibits proliferation in breast cancer are currently unknown; however, because RRS1 is one of the rRNA processing factors in ribosome biogenesis, we speculated that it may affect breast cancer proliferation by activating p53. This evidence concerns the gene TP53 and breast cancer.