Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator and known to act on cells from a variety of tissue origins including the liver, vasculature, and skin, exerting classic mitogenic activity 11 and neuroprotective role.12 Our previous study had demonstrated that FGF1 treatment ameliorated diabetes‐induced nephropathy by inhibiting inflammation via JNK/NF‐kB signalling pathway.13 But there are no studies to focus on the effect of FGF1 on cellular stress during FGF1 treatment for DN. The gene discussed is FGF1; the disease is liver dysplastic nodule.