GO and KEGG pathway analysis showed that the differentially expressed genes downstream of LMO2 were enriched for pathways associated with haematopoietic development and haematopoietic progenitors differentiation as well as several erythropoiesis related signalling pathways (Figure 4D), such as Ras,26 PI3‐kinase27, 28 and hypoxic inducible factor 1 (HIF‐1) signalling pathways.29 Our results suggest that PML‐RARα disrupts erythroid differentiation programme through repression of LMO2, and thereby leads to the inhibition of erythropoiesis in APL. This evidence concerns the gene RARA and acute promyelocytic leukemia.