PML and acute promyelocytic leukemia: Some studies regard that APL LICs are myeloid committed cells, based on the transgenic mouse models in which PML‐RARα expression is under control of more differentiated myeloid specific promoters.3, 4, 5 Interestingly, other studies have also indicated that PML‐RARα is expressed at the early stage of hematopoietic hierarchy such as multipotent progenitors rather than committed myeloid progenitors and promyelocytes only,6, 7, 8 indicating that the influence of PML‐RARα may not be limited to myeloid cells but other lineages of blood cells as well.