To identify the potential genes that might be involved in the inhibition of erythroid differentiation in the pathogenesis of APL, we screened the PML‐RARα targets that we previously discovered from genome‐wide studies.24 Interestingly, we found that PML‐RARα was significantly enriched in the distal promoter region of LMO2 (Figure 1A). Here, LMO2 is linked to acute promyelocytic leukemia.