MAPK8 and diabetes mellitus: C66, a new curcumin analogue, has anti‐inflammatory, anti‐fibrotic, antioxidative, and anti‐apoptotic properties in diabetic mice, and also significantly suppresses JNK activity.9, 10 In addition, we found that C66 has a high affinity for JNK2 in rat renal proximal tubular cells under conditions of high glucose, suggesting that C66 may directly target JNK2.11 Therefore, we suggested that the protective effects of C66 in diabetes‐induced myocardial injury are mediated by inhibiting JNK2 function.