Similarly, the functional role of Netrin-1 on mechanical allodynia and sprouting of myelinated afferent fibers in resiniferatoxin- (RTX-) induced postherpetic neuralgia (PHN) and neuropathic pain were assessed by Wu et al. According to this study, Netrin-1 expression has been increased after spinal cord injury and inflammatory cells in the wound region, which in turn increased the levels of Netrin mRNA expression after this injury. This evidence concerns the gene NTN1 and postherpetic neuralgia.