Comparable with the depletion of serum Netrin-1 level, UNC5B mRNA as well as Netrin-1 were established to be substantially diminished in diabetic kidney, while albuminuria/proteinuria was found to be overexpressed in mice with deleted UNC5B/Netrin-1 in kidney and administration of recombinant Netrin-1 considerably reduced diabetes-induced albuminuria and repressed interstitial and glomerular injuries [56]. The gene discussed is UNC5B; the disease is diabetes mellitus.