As our data suggested, ARG1 could promote the EMT process in HCC cells through upregulating the expression of N-cad, Vimentin, and β-catenin both at protein and mRNA levels, which was further supported by the downregulation of N-cad, Vimentin, and β-catenin and upregulation of E-cadherin in ARG1 knockdown cells. Here, ARG1 is linked to hepatocellular carcinoma.