Given that changes in GLP-1 secretion in response to nutrients and other interventions is of interest to the fields of obesity and diabetes, the robust glycemic and satiety hormone response produced by dextrose and its ease of formulation, may make it an appropriate, if not superior, means of identifying the effects of experimental diets/therapies on biochemical markers of appetite. Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.