In this context, CXCR3 functions include: (i) the recruitment of activated Th1 cells to inflamed tissues (31–33), (ii) the regulation of skin-homing autoreactive CD8+ T cells in graft-versus-host-disease (GVHD) (34), and (iii) the rapid recruitment of NK cells to antigen-stimulated lymph nodes and the facilitation of Th1 subset priming (35). The gene discussed is CXCR3; the disease is graft versus host disease.