CXCR4 and experimental autoimmune encephalomyelitis: For example, CXCL12 polarizes CXCR4+ macrophages into IL-10-secreting M2-like macrophages (16) and CXCR4+CD4+ T cells into IL-10-producing regulatory T cells (Tr1) that suppress experimental autoimmune encephalomyelitis (EAE) (17).