TCF3 and acute lymphoblastic leukemia: Genetic abnormalities associated with ALL cases are not homogeneous, and the most common mutations associated with the Ph-like subtype are the IKAROS family zinc finger 1 (IKZF1), paired box 5 (PAX5), early B-cell factor 1 (EBF1), and transcription factor 3 (E2A) (Mullighan et al., 2007).