In our research, we performed stratification analyses for SIRT1 to explore the role of the polymorphism in the subgroup population (Table 5).For rs4746720, subjects harboring the CC or TT genotype had a significantly increased risk of T2DM compared with the CT genotype, especially in which have high triglyceride, eat more red meat, with sugar food and smoking. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.