Additionally, it was reported that miR-34 loci methylation was related to the increased risk of non-small-cell lung cancer (34), possibly by altering methylation status of miR-34b/c to affect p53 expression, similar to the mechanism by which miR-34b/c rs4938723 polymorphism affect p53 expression and carcinogenesis of glioma. The gene discussed is TP53; the disease is central nervous system cancer.