It is reported that miR-34a could not only inhibit glioma stem cell proliferation, self-renewal and migration via targeting sirtuin1 (SIRT1), induce tumor cell apoptosis and differentiation (16), but also inhibit glioma cells progression and chemo resistance via targeting programmed death ligand 1 (PD-L1) (17). The gene discussed is SIRT1; the disease is glioma.