The overexpression of oxoglutarate dehydrogenase (OGDC) and isocitrate dehydrogenase (IDH), two enzymes that facilitate the use of the TCA cycle in the forward and reverse directions (i.e., oxidation or reduction of α-ketoglutarate, respectively) (27), support the idea of metabolic plasticity in CLL. This evidence concerns the gene OGDH and B-cell chronic lymphocytic leukemia.