The overexpression of oxoglutarate dehydrogenase (OGDC) and isocitrate dehydrogenase (IDH), two enzymes that facilitate the use of the TCA cycle in the forward and reverse directions (i.e., oxidation or reduction of α-ketoglutarate, respectively) (27), support the idea of metabolic plasticity in CLL. The gene discussed is IDH3A; the disease is B-cell chronic lymphocytic leukemia.