HHIP and neoplasm: We also found that pictilisib downregulated HHIP. Because PI3K signaling regulates the activity of GLI transcription factors in many other tumor entities [e.g., (19, 20, 45, 46)], it is now tempting to speculate that ERMS follows a similar scenario, in which the HH pathway in ERMS is regulated in a non-canonical manner.