These findings imply that the Wnt-Fgf10 epithelial-mesenchymal cross-talk and Shh pathway may function as an interactive signaling network in airway and alveolar remodeling responses to chronic injury in asthma, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Here, FGF10 is linked to chronic obstructive pulmonary disease.