APOE and Alzheimer disease: Our results of QTL analysis for Aβ42, T-tau/Aβ42 ratio, p-tau/Aβ42 ratio and ADAS13 (Supplementary Tables S1–S4) were illustrated in the Manhattan plots (Figure 2), showing that almost all SNPs significantly associated with AD (p-value < 10-7) are located at the chromosome 19 which contains APOE gene.