Reduced numbers of CD4 and CD8 T cells (60, 64, 68) with an immunosuppressed profile (79) was found in SLNs, a profile associated with accumulation of FoxP3+ Treg CD4 cells in LNs harboring metastases (80–83) and worse prognosis/more widespread nodal disease in melanoma, breast, and gastric cancer (82–85). The gene discussed is CD4; the disease is melanoma.