IL-6, GM-CSF, IL-12 p40, IL-1α, IL-1β, TNF-α, GROα, Eotaxin-2, M-CSF, RANTES, and MCP-1 secretion in RA patients were suppressed under SIN or MTX treatment (Figures 7A–H,J–L). This evidence concerns the gene IL6 and rheumatoid arthritis.